of prostate cancer on the basis of serum PSA elevation and/or DRE findings.
For men in high-risk groups, such as African Americans or men with a first-degree relative diagnosed at a younger age, testing should begin at a younger age. Circulating levels of prostate-specific antigen (PSA) and testosterone are. The American Cancer Society recommends annual examination with digital rectal examination and serum PSA beginning at age 50, and for those men with a life expectancy of at least 10 years after detection of prostate cancer. The role of PSA in early detection of prostate cancer is controversial. In patients with previously diagnosed prostate cancer, PSA testing is advocated as an early indicator of tumor recurrence and as an indicator of response to therapy. Higher levels of PSA can be found in the blood as prostate cancer cells begin to proliferate in an uncontrolled way. An abnormal rise in PSA, can indicate Prostate Cancer. Massimo Lazzeri Department of Urology, San Raffaele Turro, Vita-Salute San Raffaele University, Milan, Italy. Prostate Specific Antigen or PSA, is an enzyme found in a man's blood produced exclusively by prostate cells. PSA Density: The vast majority of men (80) with elevated PSA have serum. Increases in glandular size and tissue damage caused by benign prostatic hypertrophy, prostatitis, or prostate cancer may increase circulating PSA levels. Serum index test -2proPSA and Prostate Health Index are more accurate than prostate specific antigen and fPSA in predicting a positive repeat prostate biopsy. A change in PSA of more than 0.5 ng/ml per year indicates presence of prostate cancer.
Normally, very little PSA is secreted in the blood. Prostate-specific antigen (PSA) is a glycoprotein that is produced by the prostate gland, the lining of the urethra, and the bulbourethral gland.
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